Loss of alpha 1 connexin does not alter the prenatal differentiation of pancreatic beta cells and leads to the identification of another islet cell connexin.

@article{Charollais1999LossOA,
  title={Loss of alpha 1 connexin does not alter the prenatal differentiation of pancreatic beta cells and leads to the identification of another islet cell connexin.},
  author={Anne Charollais and V Serre and Charles N. Mock and F Cogne and Domenico Bosco and Paolo Meda},
  journal={Developmental genetics},
  year={1999},
  volume={24 1-2},
  pages={13-26}
}
Connexin alpha 1, also referred to as Cx43, has thus far been the only gap junction protein identified between the hormone-producing cells of pancreatic islets. To investigate whether loss of this connexin affects the development of endocrine pancreas and the differentiation of insulin-producing beta cells, we have taken advantage of a transgenic line in which the gene coding for connexin alpha 1 had been functionally deleted by homologous recombination. Analysis of pancreas at embryonal day 19… CONTINUE READING

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