Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma

@article{Zbar1987LossOA,
  title={Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma},
  author={Berton Zbar and Hiltrud Brauch and Cathy B Talmadge and Marston Linehan},
  journal={Nature},
  year={1987},
  volume={327},
  pages={721-724}
}
Loss of genes at specific chromosomal loci is a characteristic of retinoblastoma1, Wilms' tumour11, transitional cell carcinoma of the bladder2, embryonal tumours3 and small cell carcinoma of the lung4–7. The significance of nonrandom gene loss in these neoplasms is that gene loss on one chromosome may uncover null mutations at corresponding loci of the homologous chromosome8,9. Loss of specific gene products from somatic cells may be critical in the origin or evolution of certain human tumours… CONTINUE READING
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