Loss of activator protein-2alpha results in overexpression of protease-activated receptor-1 and correlates with the malignant phenotype of human melanoma.

@article{Tellez2003LossOA,
  title={Loss of activator protein-2alpha results in overexpression of protease-activated receptor-1 and correlates with the malignant phenotype of human melanoma.},
  author={Carmen Tellez and Michael D. Mccarty and Maribelis Ruiz and Menashe M Bar-Eli},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 47},
  pages={
          46632-42
        }
}
Increasing evidence implicates the protease-activated receptor-1 (PAR-1) as a contributor to tumor invasion and metastasis of human melanoma. Here we demonstrate that the metastatic potential of human melanoma cells correlates with overexpression of PAR-1. We also provide evidence that an inverse correlation exists between the expression of activator protein-2alpha (AP-2) and the expression of PAR-1 in human melanoma cells. Reexpression of AP-2 in WM266-4 melanoma cells, which are AP-2-negative… CONTINUE READING

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Pigment Cell Res

  • M. Bar-Eli
  • J. Biol. Chem. 10.1074/jbc.M309159200
  • 2001
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