Loss of a renal graft due to recurrence of anti-GBM disease despite rituximab therapy.

Abstract

The recurrence of anti-glomerular basement membrane (anti-GBM) glomerulonephritis (GN) in renal transplants is very rare. We report on a patient that developed acute renal allograft dysfunction due to anti-GBM GN relapse 18 months after transplantation. As plasmaseperation, dose escalation of MMF, steroids and cyclophosphamids did not result in an improvement of the graft function, a therapy with the anti-CD20 antibody Rituximab was established in addition to plasmaseperation, cyclophosphamid and steroids. Although this resulted in a decrease of anti-GBM antibody titer, graft function deteriorated further and a renal replacement therapy had to be initiated.

DOI: 10.1111/j.1399-0012.2008.00912.x

Cite this paper

@article{Sauter2009LossOA, title={Loss of a renal graft due to recurrence of anti-GBM disease despite rituximab therapy.}, author={Matthias Sauter and Holger Schmid and Hans J . Anders and Florian Heller and Max Weiss and Thomas Sitter}, journal={Clinical transplantation}, year={2009}, volume={23 1}, pages={132-6} }