Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling.

@article{Kobielak2007LossOA,
  title={Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling.},
  author={Krzysztof Kobielak and N. Stokes and June de la Cruz and Lisa Polak and Elaine Fuchs},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 24},
  pages={10063-8}
}
During the hair cycle, follicle stem cells (SCs) residing in a specialized niche called the "bulge" undergo bouts of quiescence and activation to cyclically regenerate new hairs. Developmental studies have long implicated the canonical bone morphogenetic protein (BMP) pathway in hair follicle (HF) determination and differentiation, but how BMP signaling functions in the hair follicle SC niche remains unknown. Here, we use loss and gain of function studies to manipulate BMP signaling in the SC… CONTINUE READING
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Stem Cells 24:2826–2839

  • J Zhang, XC He, +5 authors L Li
  • 2006

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