Loss of a negative feedback loop involving pea3 and cyclin d2 is required for pea3-induced migration in transformed mammary epithelial cells.

@article{Ladam2013LossOA,
  title={Loss of a negative feedback loop involving pea3 and cyclin d2 is required for pea3-induced migration in transformed mammary epithelial cells.},
  author={Franck Ladam and Isabelle Damour and Patrick Dumont and Zoulika Kherrouche and Yvan de Launoit and David Tulasne and Anne Chotteau-Leli{\`e}vre},
  journal={Molecular cancer research : MCR},
  year={2013},
  volume={11 11},
  pages={1412-24}
}
UNLABELLED The Ets family transcription factor Pea3 (ETV4) is involved in tumorigenesis especially during the metastatic process. Pea3 is known to induce migration and invasion in mammary epithelial cell model systems. However, the molecular pathways regulated by Pea3 are still misunderstood. In the current study, using in vivo and in vitro assays, Pea3 increased the morphogenetic and tumorigenic capacity of mammary epithelial cells by modulating their cell morphology, proliferation, and… CONTINUE READING