Loss of a 20S Proteasome Activator in Saccharomyces cerevisiae Downregulates Genes Important for Genomic Integrity, Increases DNA Damage, and Selectively Sensitizes Cells to Agents With Diverse Mechanisms of Action

@inproceedings{Doherty2012LossOA,
  title={Loss of a 20S Proteasome Activator in Saccharomyces cerevisiae Downregulates Genes Important for Genomic Integrity, Increases DNA Damage, and Selectively Sensitizes Cells to Agents With Diverse Mechanisms of Action},
  author={Kevin M. Doherty and Leah D. Pride and James Lukose and Brian E. Snydsman and Ronald Charles and Ajay Pramanik and Eric G. D. Muller and David Botstein and Carol Wood Moore},
  booktitle={G3},
  year={2012}
}
Cytoprotective functions of a 20S proteasome activator were investigated. Saccharomyces cerevisiae Blm10 and human 20S proteasome activator 200 (PA200) are homologs. Comparative genome-wide analyses of untreated diploid cells lacking Blm10 and growing at steady state at defined growth rates revealed downregulation of numerous genes required for accurate… CONTINUE READING