Loss of WISP2/CCN5 in Estrogen-Dependent MCF7 Human Breast Cancer Cells Promotes a Stem-Like Cell Phenotype

@inproceedings{Ferrand2014LossOW,
  title={Loss of WISP2/CCN5 in Estrogen-Dependent MCF7 Human Breast Cancer Cells Promotes a Stem-Like Cell Phenotype},
  author={Nathalie Ferrand and Anne Gnanapragasam and Guillaume Doroth{\'e}e and G{\'e}rard Redeuilh and Annette K. Larsen and Mich{\`e}le Sabbah},
  booktitle={PloS one},
  year={2014}
}
It has been proposed that the epithelial-mesenchymal transition (EMT) in mammary epithelial cells and breast cancer cells generates stem cell features. WISP2 (Wnt-1-induced signaling protein-2) plays an important role in maintenance of the differentiated phenotype of estrogen receptor-positive breast cancer cells and loss of WISP2 is associated with EMT. We now report that loss of WISP2 in MCF7 breast cancer cells can also promote the emergence of a cancer stem-like cell phenotype characterized… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 59 REFERENCES

Identification of a GalphaGbetagamma, AKT and PKCalpha signalome associated with invasive growth in two genetic models of human breast cancer cell epithelial-to-mesenchymal transition

R Ouelaa-Benslama, O De Wever, A Hendrix, M Sabbah, K Lambein
  • Int J Oncol
  • 2012
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

CCN5/WISP-2: A micromanager of breast cancer progression

  • Journal of Cell Communication and Signaling
  • 2012
VIEW 1 EXCERPT