Loss of Usp9x Disrupts Cortical Architecture, Hippocampal Development and TGFβ-Mediated Axonogenesis

@inproceedings{Stegeman2013LossOU,
  title={Loss of Usp9x Disrupts Cortical Architecture, Hippocampal Development and TGFβ-Mediated Axonogenesis},
  author={Shane Stegeman and Lachlan A. Jolly and Susitha Premarathne and Jozef G{\'e}cz and Linda J. Richards and Alan Mackay-Sim and Stephen A Wood},
  booktitle={PloS one},
  year={2013}
}
The deubiquitylating enzyme Usp9x is highly expressed in the developing mouse brain, and increased Usp9x expression enhances the self-renewal of neural progenitors in vitro. USP9X is a candidate gene for human neurodevelopmental disorders, including lissencephaly, epilepsy and X-linked intellectual disability. To determine if Usp9x is critical to mammalian brain development we conditionally deleted the gene from neural progenitors, and their subsequent progeny. Mating Usp9x(loxP/loxP) mice with… CONTINUE READING
21 Citations
74 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 74 references

Similar Papers

Loading similar papers…