Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice.

@article{Anderson2005LossOU,
  title={Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice.},
  author={Christopher J. Anderson and Stephen Crimmins and Julie A. Wilson and Greg A Korbel and Hidde L. Ploegh and Scott McG Wilson},
  journal={Journal of neurochemistry},
  year={2005},
  volume={95 3},
  pages={724-31}
}
The ataxia (ax(J)) mutation is a spontaneous recessive mutation that results in reduced expression of ubiquitin-specific protease 14, Usp14. Mice homozygous for the ax(J) mutation are retarded for growth and exhibit several behavioral disorders, including a resting tremor and hindlimb paralysis. Although pathological defects appear to be limited to the central nervous system, reduction of Usp14 expression was widespread in the ax(J) mice. Usp14 co-fractionated with proteasomes isolated from… CONTINUE READING

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