Loss of Trop2 promotes carcinogenesis and features of epithelial to mesenchymal transition in squamous cell carcinoma.

@article{Wang2011LossOT,
  title={Loss of Trop2 promotes carcinogenesis and features of epithelial to mesenchymal transition in squamous cell carcinoma.},
  author={Jianbo Wang and Kaihua Zhang and Dorota Grabowska and Aimin Li and Yiyu Dong and Ryan Day and Peter A. Humphrey and James J. Lewis and Raleigh D. Kladney and Jeffrey Arbeit and Jason David Weber and Christine H. Chung and Loren Scott Michel},
  journal={Molecular cancer research : MCR},
  year={2011},
  volume={9 12},
  pages={
          1686-95
        }
}
Trop2, an oncogenic cell surface protein under investigation as a therapeutic target, is commonly overexpressed in several epithelial tumor types yet its function in tumor biology remains relatively unexplored. To investigate the role of Trop2 in epithelial carcinogenesis, we generated Trop2(-/-) mice, which are viable and possess a normal lifespan. Contrary to expectations, Trop2 loss fails to suppress keratinocyte transformation. Instead, ras-transformed Trop2(-/-) keratinocytes… CONTINUE READING
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