Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor–TRAF6 signaling

@inproceedings{Varney2015LossOT,
  title={Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor–TRAF6 signaling},
  author={Melinda E. Varney and Madeline Niederkorn and Hiroyasu Konno and Takayuki Matsumura and Jin Gohda and Nobuaki Yoshida and Taishin Akiyama and Susanne Christie and Jing Fang and David Miller and Andr{\'e}s Jerez and Aly Karsan and Jaroslaw Maciejewski and Ruhikanta A. Meetei and Jun-Ichiro Inoue and Daniel T. Starczynowski},
  booktitle={The Journal of experimental medicine},
  year={2015}
}
TRAF-interacting protein with forkhead-associated domain B (TIFAB) is a haploinsufficient gene in del(5q) myelodysplastic syndrome (MDS). Deletion of Tifab results in progressive bone marrow (BM) and blood defects, including skewed hematopoietic stem/progenitor cell (HSPC) proportions and altered myeloid differentiation. A subset of mice transplanted with Tifab knockout (KO) HSPCs develop a BM failure with neutrophil dysplasia and cytopenia. In competitive transplants, Tifab KO HSPCs are out… CONTINUE READING
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