Loss of TLR2 worsens spontaneous colitis in MDR1A deficiency through commensally induced pyroptosis.

  title={Loss of TLR2 worsens spontaneous colitis in MDR1A deficiency through commensally induced pyroptosis.},
  author={Birgit Ey and Annette Eyking and Magdalena Klepak and Nita H. Salzman and Joachim R G{\"o}thert and Michael Ruenzi and Kurt Werner Schmid and Guido G H Gerken and Daniel K. Podolsky and Elke Cario},
  journal={Journal of immunology},
  volume={190 11},
Variants of the multidrug resistance gene (MDR1/ABCB1) have been associated with increased susceptibility to severe ulcerative colitis (UC). In this study, we investigated the role of TLR/IL-1R signaling pathways including the common adaptor MyD88 in the pathogenesis of chronic colonic inflammation in MDR1A deficiency. Double- or triple-null mice lacking TLR2, MD-2, MyD88, and MDR1A were generated in the FVB/N background. Deletion of TLR2 in MDR1A deficiency resulted in fulminant pancolitis… CONTINUE READING


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