Loss of TGF-β1 Leads to Increased Neuronal Cell Death and Microgliosis in Mouse Brain

  title={Loss of TGF-β1 Leads to Increased Neuronal Cell Death and Microgliosis in Mouse Brain},
  author={Thomas C. Brionne and Ina Tesseur and Eliezer Masliah and Tony Wyss-Coray},
TGF-beta1 is a key regulator of diverse biological processes in many tissues and cell types, but its exact function in the developing and adult mammalian CNS is still unknown. We report that lack of TGF-beta1 expression in neonatal Tgfb1(-/-) mice results in a widespread increase in degenerating neurons accompanied by reduced expression of synaptophysin and laminin and a prominent microgliosis. Lack of TGF-beta1 also strongly reduces survival of primary neurons cultured from Tgfb1(-/-) mice… CONTINUE READING
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