Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes.

  title={Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes.},
  author={Vladimir V. Sharoyko and Mia Abels and Jiangming Sun and Lisa M. Nicholas and In{\^e}s Guerra Mollet and Jelena A. Stamenkovic and Isabel G{\"o}hring and Siri Malmgren and Petter Storm and Jo{\~a}o Fadista and Peter Sp{\'e}gel and Metodi D Metodiev and Nils-G{\"o}ran Larsson and Lena Eliasson and Nils Wierup and Hindrik Mulder},
  journal={Human molecular genetics},
  volume={23 21},
We have previously identified transcription factor B1 mitochondrial (TFB1M) as a type 2 diabetes (T2D) risk gene, using human and mouse genetics. To further understand the function of TFB1M and how it is associated with T2D, we created a β-cell-specific knockout of Tfb1m, which gradually developed diabetes. Prior to the onset of diabetes, β-Tfb1m(-/-) mice exhibited retarded glucose clearance owing to impaired insulin secretion. β-Tfb1m(-/-) islets released less insulin in response to fuels… 

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