Loss of Smu1 function de-represses DNA replication and over-activates ATR-dependent replication checkpoint.

@article{Ren2013LossOS,
  title={Loss of Smu1 function de-represses DNA replication and over-activates ATR-dependent replication checkpoint.},
  author={Laifeng Ren and Yao Liu and Liandi Guo and Haibin Wang and Miaozhang Zhu and Ming Zeng and Xin Yu Shao and Chunlei Yang and Yaxiong Tang and Lei Wang and Cong Liu and Mingyuan Li},
  journal={Biochemical and biophysical research communications},
  year={2013},
  volume={436 2},
  pages={192-8}
}
Smu1 is an evolutionarily conserved gene that encodes a member of the WD40-repeat protein family. Disruption of Smu1 function leads to multiple cellular defects including chromosomal instability, aberrant DNA replication and alternative RNA splicing events. In this paper, we show that Smu1 is a chromatin-bound protein that functions as a negative regulator of DNA replication. Knockdown of Smu1 gene expression promotes excessive incorporation of dNTP analogue, implicating the acceleration of DNA… CONTINUE READING

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