Loss of Smad4 expression predicts liver metastasis in human colorectal cancer.

@article{Losi2007LossOS,
  title={Loss of Smad4 expression predicts liver metastasis in human colorectal cancer.},
  author={Lorena Losi and Hanifa Bouzour{\`e}ne and Jean Benhattar},
  journal={Oncology reports},
  year={2007},
  volume={17 5},
  pages={1095-9}
}
Distant metastases represent the major cause of death after curative surgery of colorectal cancer. The aim of this study was to evaluate the role of Smad4 and KRAS genetic alterations in colorectal metastases taking into account both the site (hepatic versus extrahepatic) and the time (synchronous versus metachronous) of recurrence. We examined the immunohistochemical expression of Smad4 and frequency of KRAS mutation in primary colorectal tumors and in their corresponding metastatic tissues… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

The Role of Chemokines in Promoting Colorectal Cancer Invasion/Metastasis

International journal of molecular sciences • 2016
View 1 Excerpt

Similar Papers

Loading similar papers…