Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-β1 production

  title={Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-β1 production},
  author={Hisanobu Ogata and Takatoshi Chinen and Takafumi Yoshida and Ichiko Kinjyo and Giichi Takaesu and Hiroshi Shiraishi and Mari Iida and Toshiko Kobayashi and Akihiko Yoshimura},
Recently, DNA methylation and reduced expression of the suppressor of the cytokine signaling-3 (SOCS3) gene in human hepatocellular carcinoma (HCC) patients have been reported. However, the roles of SOCS3 in HCC development in vivo have not been clarified. Using RT–PCR analysis and Western blotting, we confirmed that SOCS3 expression was reduced in HCC patients. However, reduced expression of SOCS3 occurred not only in HCC but also in nontumor regions, and this reduction was stronger as the… CONTINUE READING

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