Loss of SIRT4 decreases GLT-1-dependent glutamate uptake and increases sensitivity to kainic acid.

@article{Shih2014LossOS,
  title={Loss of SIRT4 decreases GLT-1-dependent glutamate uptake and increases sensitivity to kainic acid.},
  author={Jennifer C. Shih and Lei Liu and Andrew O Mason and Haruki Higashimori and Gizem Donmez},
  journal={Journal of neurochemistry},
  year={2014},
  volume={131 5},
  pages={573-81}
}
Glutamate transport is a critical process in the brain that maintains low extracellular levels of glutamate to allow for efficient neurotransmission and prevent excitotoxicity. Loss of glutamate transport function is implicated in epilepsy, traumatic brain injury, and amyotrophic lateral sclerosis. It remains unclear whether or not glutamate transport can be modulated in these disease conditions to improve outcome. Here, we show that sirtuin (SIRT)4, a mitochondrial sirtuin, is up-regulated in… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Role of Sirtuins in Linking Metabolic Syndrome with Depression

Front. Cell. Neurosci. • 2016
View 6 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…