Loss of RNA expression and allele-specific expression associated with congenital heart disease

@article{McKean2016LossOR,
  title={Loss of RNA expression and allele-specific expression associated with congenital heart disease},
  author={D. McKean and Jason G Homsy and H. Wakimoto and N. Patel and J. Gorham and S. DePalma and J. Ware and S. Zaidi and Wenji Ma and R. Lifton and W. Chung and R. Kim and Yufeng Shen and M. Brueckner and E. Goldmuntz and A. Sharp and C. Seidman and B. Gelb and J. Seidman},
  journal={Nature Communications},
  year={2016},
  volume={7}
}
Congenital heart disease (CHD), a prevalent birth defect occurring in 1% of newborns, likely results from aberrant expression of cardiac developmental genes. Mutations in a variety of cardiac transcription factors, developmental signalling molecules and molecules that modify chromatin cause at least 20% of disease, but most CHD remains unexplained. We employ RNAseq analyses to assess allele-specific expression (ASE) and biallelic loss-of-expression (LOE) in 172 tissue samples from 144… Expand
Genomic frontiers in congenital heart disease
Single-Cell Resolution of Temporal Gene Expression during Heart Development.
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References

SHOWING 1-10 OF 50 REFERENCES
De novo mutations in histone modifying genes in congenital heart disease
Genetics of congenital heart disease: the glass half empty.
Genome-wide assessment of imprinted expression in human cells
...
1
2
3
4
5
...