Loss of RNA–Dependent RNA Polymerase 2 (RDR2) Function Causes Widespread and Unexpected Changes in the Expression of Transposons, Genes, and 24-nt Small RNAs

@inproceedings{Jia2009LossOR,
  title={Loss of RNA–Dependent RNA Polymerase 2 (RDR2) Function Causes Widespread and Unexpected Changes in the Expression of Transposons, Genes, and 24-nt Small RNAs},
  author={Y. C. Jia and Damon Lisch and Kazuhiro Ohtsu and Michael J. Scanlon and Dan Nettleton and Patrick S. Schnable},
  booktitle={PLoS genetics},
  year={2009}
}
Transposable elements (TEs) comprise a substantial portion of many eukaryotic genomes and are typically transcriptionally silenced. RNA-dependent RNA polymerase 2 (RDR2) is a component of the RNA-directed DNA methylation (RdDM) silencing pathway. In maize, loss of mediator of paramutation1 (mop1) encoded RDR2 function results in reactivation of transcriptionally silenced Mu transposons and a substantial reduction in the accumulation of 24 nt short-interfering RNAs (siRNAs) that recruit RNA… CONTINUE READING

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Production and processing of siRNA precursor transcripts from the highly repetitive maize genome

  • CJ Hale, KF Erhard, Jr., D Lisch, JB Hollick
  • PLoS Genet 5:
  • 2009
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