Loss of RMI2 Increases Genome Instability and Causes a Bloom-Like Syndrome

Abstract

Bloom syndrome is a recessive human genetic disorder with features of genome instability, growth deficiency and predisposition to cancer. The only known causative gene is the BLM helicase that is a member of a protein complex along with topoisomerase III alpha, RMI1 and 2, which maintains replication fork stability and dissolves double Holliday junctions to… (More)
DOI: 10.1371/journal.pgen.1006483

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