Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti.

@article{Pym2002LossOR,
  title={Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti.},
  author={Alexander S. Pym and Priscille Brodin and Roland Brosch and Michel Ren{\'e} Huerre and Stewart T Cole},
  journal={Molecular microbiology},
  year={2002},
  volume={46 3},
  pages={709-17}
}
Although large human populations have been safely immunized against tuberculosis with two live vaccines, Mycobacterium bovis BCG or Mycobacterium microti, the vole bacillus, the molecular basis for the avirulence of these vaccine strains remains unknown. Comparative genomics has identified a series of chromosomal deletions common to both virulent and avirulent species but only a single locus, RD1, that has been deleted from M. bovis BCG and M. microti. Restoration of RD1, by gene knock-in… CONTINUE READING
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