Loss of RB and MTS1/CDKN2 (p16) expression in human sarcomas.

  title={Loss of RB and MTS1/CDKN2 (p16) expression in human sarcomas.},
  author={Jason A. Cohen and Joseph Geradts},
  journal={Human pathology},
  volume={28 8},
The product of the MTS1/CDKN2 gene (p16) and the retinoblastoma protein (pRB) inhibit cell cycle progression at the late G1 checkpoint. The absence of functional p16 or pRB has been identified in a variety of human tumors but has not been well studied in mesenchymal neoplasia. Using an immunohistochemical approach, the authors identified abnormal expression of either p16 or RB in 16 and 14 of 59 sarcomas, respectively, for an overall abnormality rate of 51%. Specific rates of abnormality varied… CONTINUE READING


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