Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway

Abstract

Hepatocellular carcinoma (HCC) is a deadly malignancy with limited treatment options. Activation of the AKT/mTOR cascade is one of the most frequent events along hepatocarcinogenesis. mTOR is a serine/threonine kinase and presents in two distinct complexes: mTORC1 and mTORC2. While mTORC1 has been extensively studied in HCC, the functional contribution of… (More)
DOI: 10.1038/emm.2017.158

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