Loss of Prohibitin Induces Mitochondrial Damages Altering β-Cell Function and Survival and Is Responsible for Gradual Diabetes Development

@inproceedings{Supale2013LossOP,
  title={Loss of Prohibitin Induces Mitochondrial Damages Altering β-Cell Function and Survival and Is Responsible for Gradual Diabetes Development},
  author={Sachin Supale and Fabrizio Thorel and Carsten Merkwirth and Asllan Gjinovci and Pedro L Herrera and Luca Scorrano and Paolo Meda and Thomas Langer and Pierre Maechler},
  booktitle={Diabetes},
  year={2013}
}
Prohibitins are highly conserved proteins mainly implicated in the maintenance of mitochondrial function and architecture. Their dysfunctions are associated with aging, cancer, obesity, and inflammation. However, their possible role in pancreatic β-cells remains unknown. The current study documents the expression of prohibitins in human and rodent islets and their key role for β-cell function and survival. Ablation of Phb2 in mouse β-cells sequentially resulted in impairment of mitochondrial… CONTINUE READING
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