Loss of Post-Translational Modification Sites in Disease

  title={Loss of Post-Translational Modification Sites in Disease},
  author={Shuyan Li and Lilia M. Iakoucheva and Sean D. Mooney and Predrag Radivojac},
  journal={Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing},
Understanding and predicting molecular cause of disease is one of the major challenges for biology and medicine. One particular area of interest continues to be computational analyses of disease-associated amino acid substitutions. To this end, various studies have been performed to identify molecular functions disrupted by disease-causing mutations. Here, we investigate the influence of disease-associated mutations on post-translational modifications. In particular, we study the loss of… CONTINUE READING


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