Loss of Pink1 modulates synaptic mitochondrial bioenergetics in the rat striatum prior to motor symptoms: concomitant complex I respiratory defects and increased complex II-mediated respiration.

@article{Stauch2016LossOP,
  title={Loss of Pink1 modulates synaptic mitochondrial bioenergetics in the rat striatum prior to motor symptoms: concomitant complex I respiratory defects and increased complex II-mediated respiration.},
  author={Kelly L. Stauch and Lance M. Villeneuve and Phillip R. Purnell and Brendan M. Ottemann and Katy Emanuel and Howard S. Fox},
  journal={Proteomics. Clinical applications},
  year={2016},
  volume={10 12},
  pages={
          1205-1217
        }
}
PURPOSE Mutations in PTEN-induced putative kinase 1 (Pink1), a mitochondrial serine/threonine kinase, cause a recessive inherited form of Parkinson's disease (PD). Pink1 deletion in rats results in a progressive PD-like phenotype, characterized by significant motor deficits starting at 4 months of age. Despite the evidence of mitochondrial dysfunction, the pathogenic mechanism underlying disease due to Pink1-deficiency remains obscure. EXPERIMENTAL DESIGN Striatal synaptic mitochondria from 3… CONTINUE READING
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