Loss of PTEN is associated with aggressive behavior in ERG-positive prostate cancer.

  title={Loss of PTEN is associated with aggressive behavior in ERG-positive prostate cancer.},
  author={Katri A. Leinonen and Outi R. Saram{\"a}ki and Bungo Furusato and Takahiro Kimura and Hiroyuki Takahashi and Shin Egawa and Hiroyoshi Suzuki and Kerri E Keiger and Sung Ho Hahm and William B Isaacs and Teemu Tolonen and U. H. Stenman and Teuvo L. J. Tammela and Matti Nykter and George Steven Bova and Tapio Visakorpi},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={22 12},
BACKGROUND The associations of ERG overexpression with clinical behavior and molecular pathways of prostate cancer are incompletely known. We assessed the association of ERG expression with AR, PTEN, SPINK1, Ki-67, and EZH2 expression levels, deletion, and mutations of chromosomal region 3p14 and TP53, and clinicopathologic variables. METHODS The material consisted of 326 prostatectomies, 166 needle biopsies from men treated primarily with endocrine therapy, 177 transurethral resections of… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 54 extracted citations


Publications referenced by this paper.
Showing 1-10 of 47 references

Loss of PTEN expression in paraffin-embedded primary prostate Expression of ERG in Prostate Cancer www.aacrjournals.org Cancer Epidemiol Biomarkers Prev

  • ME McMenamin, P Soung, S Perera, I Kaplan, M Loda, WR. Sellers
  • December 2013 2343 on December
  • 2013
1 Excerpt

Similar Papers

Loading similar papers…