Loss of PKC-delta alters cardiac metabolism.

@article{Mayr2004LossOP,
  title={Loss of PKC-delta alters cardiac metabolism.},
  author={Manuel Mayr and Yonsuk Lee Chung and Ursula Mayr and Emma McGregor and Helen Troy and Gottfried Baier and Michael Leitges and Michael J. Dunn and John R. Griffiths and Qingbo Xu},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2004},
  volume={287 2},
  pages={
          H937-45
        }
}
PKC-delta is believed to play an essential role in cardiomyocyte growth. In the present study, we investigated the effect of PKC-delta on cardiac metabolism using PKC-delta knockout mice generated in our laboratories. Proteomic analysis of heart protein extracts revealed profound changes in enzymes related to energy metabolism: certain isoforms of glycolytic enzymes, e.g., lactate dehydrogenase and pyruvate kinase, were absent or decreased, whereas several enzymes involved in lipid metabolism… CONTINUE READING

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