Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission.

@article{Dagda2009LossOP,
  title={Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission.},
  author={Ruben K Dagda and Salvatore J. Cherra and Scott M. Kulich and Anurag Tandon and David Park and Charleen T Chu},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 20},
  pages={13843-55}
}
Mitochondrial dysregulation is strongly implicated in Parkinson disease. Mutations in PTEN-induced kinase 1 (PINK1) are associated with familial parkinsonism and neuropsychiatric disorders. Although overexpressed PINK1 is neuroprotective, less is known about neuronal responses to loss of PINK1 function. We found that stable knockdown of PINK1 induced mitochondrial fragmentation and autophagy in SH-SY5Y cells, which was reversed by the reintroduction of an RNA interference (RNAi)-resistant… CONTINUE READING
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PINK1 Regulates Mitochondrial Fission and Autophagy 13854 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

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