Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress.

@article{Guo2010LossOP,
  title={Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress.},
  author={Danny Guo and Zamaneh Kassiri and Ratnadeep Basu and Fung Lan Chow and Vijay S. Kandalam and Federico Damilano and Wenbin Liang and Seigo Izumo and Emilio Hirsch and Josef M. Penninger and Peter Backx and Gavin Yadram Oudit},
  journal={Circulation research},
  year={2010},
  volume={107 10},
  pages={
          1275-89
        }
}
RATIONALE Mechanotransduction and the response to biomechanical stress is a fundamental response in heart disease. Loss of phosphoinositide 3-kinase (PI3K)γ, the isoform linked to G protein-coupled receptor signaling, results in increased myocardial contractility, but the response to pressure overload is controversial. OBJECTIVE To characterize molecular and cellular responses of the PI3Kγ knockout (KO) mice to biomechanical stress. METHODS AND RESULTS In response to pressure overload, PI3K… CONTINUE READING

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