Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis.

Abstract

A common feature of inflammatory bowel disease (IBD) is the loss of intestinal epithelial barrier function due to excessive apoptosis of intestinal epithelial cells (IECs). However, the molecular mechanism underlying increased IEC apoptosis remains unclear. Here, we investigated the role of PHLPP, a novel family of protein phosphatases, in regulating… (More)
DOI: 10.1016/j.bbadis.2015.07.012

Topics

6 Figures and Tables

Cite this paper

@article{Wen2015LossOP, title={Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis.}, author={Yang-an Wen and Xin Li and Tatiana Goretsky and Heidi L. Weiss and Terrence A. Barrett and Tianyan Gao}, journal={Biochimica et biophysica acta}, year={2015}, volume={1852 10 Pt A}, pages={2013-23} }