Loss of PDZ-adaptor protein NHERF2 affects membrane localization and cGMP- and [Ca2+]- but not cAMP-dependent regulation of Na+/H+ exchanger 3 in murine intestine.

Abstract

Trafficking and regulation of the epithelial brush border membrane (BBM) Na+/H+ exchanger 3 (NHE3) in the intestine involves interaction with four different members of the NHERF family in a signal-dependent and possibly segment-specific fashion. The aim of this research was to study the role of NHERF2 (E3KARP) in intestinal NHE3 BBM localization and second… (More)
DOI: 10.1113/jphysiol.2010.198721

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@article{Chen2010LossOP, title={Loss of PDZ-adaptor protein NHERF2 affects membrane localization and cGMP- and [Ca2+]- but not cAMP-dependent regulation of Na+/H+ exchanger 3 in murine intestine.}, author={Mingmin Chen and Ayesha Sultan and Ayhan Cinar and Sunil Yeruva and Brigitte Riederer and Anurag K. Singh and Junhua Li and Janina Bonhagen and Gang Chen and Chris C Yun and Mark Donowitz and Boris M Hogema and Hugo de Jonge and Ursula Seidler}, journal={The Journal of physiology}, year={2010}, volume={588 Pt 24}, pages={5049-63} }