Loss of P16INK4 expression is frequent in high grade gliomas.

  title={Loss of P16INK4 expression is frequent in high grade gliomas.},
  author={Ryo Nishikawa and Frank B Furnari and H M Lin and Wadih Arap and Mitchel S. Berger and Webster K Cavenee and H J Su Huang},
  journal={Cancer research},
  volume={55 9},
P16INK4 is a cell cycle regulator that specifically binds to and inactivates cyclin-dependent kinase 4 (CDK4). Its encoding gene (p16/CDKN2) maps to chromosome 9p21, a region that undergoes frequent loss of heterozygosity in a variety of human tumors. We have analyzed the p16/CDKN2 gene and its expression in a series of primary glioma samples. Although homozygous deletion or mutation of the p16/CDKN2 gene was uncommon in this series and P16INK4 protein was detectable in all grade II tumors, it… CONTINUE READING

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