Loss of Nrf2 promotes rapid progression to heart failure following myocardial infarction.

@article{Strom2017LossON,
  title={Loss of Nrf2 promotes rapid progression to heart failure following myocardial infarction.},
  author={Joshua G. Strom and Qin M. Chen},
  journal={Toxicology and applied pharmacology},
  year={2017},
  volume={327},
  pages={52-58}
}
Nrf2 gene encodes a transcription factor regulating the expression of antioxidant and detoxification genes. We test here whether Nrf2 plays a role for cardiac protection during ischemic injury in an effort to establish Nrf2 as a target for cardiac protection therapies. Cardiac ischemia induced by the left anterior descending (LAD) coronary artery ligation results in myocardial infarction (MI). Young mice surviving MI show minimal signs of heart failure. Mice lacking Nrf2 experience an… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 4 times. VIEW TWEETS