Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis.

  title={Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis.},
  author={Sudhir Chowdhry and Maiiada Hasan Nazmy and Paul J Meakin and Albena T Dinkova-Kostova and Shaun V Walsh and Tadayuki Tsujita and John F. Dillon and Michael L J Ashford and John D. Hayes},
  journal={Free radical biology & medicine},
  volume={48 2},
Nonalcoholic steatohepatitis (NASH) arises from nonalcoholic fatty liver disease (NAFLD) as a consequence of oxidative stress. Herein we report that the development of NASH is greatly accelerated in mice lacking transcription factor Nrf2 when they are challenged with a methionine- and choline-deficient (MCD) diet. After 14 days of feeding on an MCD diet, livers from Nrf2(-/-) mice showed a substantial increase in macro- and microvesicular steatosis and a massive increase in the number of… CONTINUE READING
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