Loss of Na+ channel beta2 subunits is neuroprotective in a mouse model of multiple sclerosis.

@article{OMalley2009LossON,
  title={Loss of Na+ channel beta2 subunits is neuroprotective in a mouse model of multiple sclerosis.},
  author={Heather A O'Malley and Andrew B. Shreiner and Gwo-hsiao Chen and Gary B Huffnagle and Lori L Isom},
  journal={Molecular and cellular neurosciences},
  year={2009},
  volume={40 2},
  pages={143-55}
}
Multiple sclerosis (MS) is a CNS disease that includes demyelination and axonal degeneration. Voltage-gated Na+ channels are abnormally expressed and distributed in MS and its animal model, Experimental Allergic Encephalomyelitis (EAE). Up-regulation of Na+ channels along demyelinated axons is proposed to lead to axonal loss in MS/EAE. We hypothesized that Na+ channel beta2 subunits (encoded by Scn2b) are involved in MS/EAE pathogenesis, as beta2 is responsible for regulating levels of channel… CONTINUE READING

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