Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression.

@article{LpezRodrguez2004LossON,
  title={Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression.},
  author={Cristina L{\'o}pez-Rodr{\'i}guez and Christopher L Antos and John M. Shelton and James A. Richardson and Fangming Lin and Tatiana I. Novobrantseva and Roderick T Bronson and Peter Igarashi and Anjana Rao and Eric N. Olson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 8},
  pages={
          2392-7
        }
}
The transcription factor NFAT5/TonEBP, a member of the NFAT/Rel family of transcription factors, has been implicated in diverse cellular responses, including the response to osmotic stress, integrin-dependent cell migration, T cell activation, and the Ras pathway in Drosophila. To clarify the in vivo role of NFAT5, we generated NFAT5-null mice. Homozygous mutants were genetically underrepresented after embryonic day 14.5. Surviving mice manifested a progressive and profound atrophy of the… Expand
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It is suggested that Dox promoted the degradation of NFAT5 protein, reducing cell viability in cardiomyocytes, and this is the first demonstration thatNFAT5 is a positive regulator ofCardiomyocyte survival. Expand
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  • Biology, Medicine
  • World journal of nephrology
  • 2016
TLDR
The present article reviews the effect of each kinase on NFAT5 nuclear localization, transactivation and protein abundance, and the relationship among these kinases, if known and reiterates the concept of signaling through cooperation. Expand
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TLDR
New data demonstrate that tonicity-independent stimulation of TonEBP is critical for tissue-specific functions like enhanced cell survival, migration, proliferation, vascular remodeling, carcinoma invasion, and angiogenesis. Expand
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Current knowledge on the functional roles of NFAT5 in osmotic stress adaptation and the signaling pathways that regulate its activity are summarized. Expand
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References

SHOWING 1-10 OF 21 REFERENCES
TonEBP transcriptional activator in the cellular response to increased osmolality
TLDR
TonEBP plays a significant role in immunity by stimulating several cytokine genes in the T-cells by regulating changes in diuretic status mainly at the level of nucleocytoplasmic distribution. Expand
Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity.
TLDR
CDNA cloning of human TonE binding protein (TonEBP) is reported, a transcription factor that stimulates transcription through its binding to TonE sequences via a Rel-like DNA binding domain that plays a key role in hypertonicity-induced transcriptional stimulation of SMIT, sodium/chloride/betaine cotransporter, and aldose reductase. Expand
Bridging the NFAT and NF-κB Families
TLDR
It is suggested that NFAT5 participates in specific aspects of host defense by upregulating TNF family genes and other target genes in T cells by regulating expression of the TNFα and lymphotoxin-β genes in osmotically stressed T cells. Expand
The NFAT-Related Protein NFATL1 (TonEBP/NFAT5) Is Induced Upon T Cell Activation in a Calcineurin-Dependent Manner1
  • J. Trama, Qingjun Lu, R. Hawley, Steffan N. Ho
  • Biology, Medicine
  • The Journal of Immunology
  • 2000
TLDR
Inducible expression of NFATL1 represents a mechanism by which receptor-dependent signals as well as osmotic stress signals are translated into transcriptional responses that regulate cell function. Expand
Hydration status affects nuclear distribution of transcription factor tonicity responsive enhancer binding protein in rat kidney.
  • J. Cha, S. K. Woo, +4 authors H. Kwon
  • Biology, Medicine
  • Journal of the American Society of Nephrology : JASN
  • 2001
TLDR
It is concluded that under physiologic conditions, nucleocytoplasmic distribution is the dominant mode of regulation of TonEBP in the renal medulla. Expand
NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun.
TLDR
An NFAT-related protein, NFAT5, is identified, which differs from the conventional NFAT proteins NFAT1-4 in its structure, DNA binding, and regulation, and participates in as-yet-unidentified signaling pathways in diverse immune and nonimmune cells. Expand
Identification and Characterization of Multiple Osmotic Response Sequences in the Human Aldose Reductase Gene*
TLDR
The data indicate that cooperative interaction among the three TonE-like sequences in the human AR may be necessary for their enhancer function, suggesting that the mechanism of osmotic regulation of gene expression in these animals is similar. Expand
Structure of a TonEBP–DNA complex reveals DNA encircled by a transcription factor
TLDR
The list of proteins that bind DNA by encirclement is now expanded to include sequence-specific transcription factors, providing a direct structural link between the NFAT and NF-κB family of transcription factors. Expand
The role of NFAT transcription factors in integrin-mediated carcinoma invasion
TLDR
Observations show that NFATs are targets of α6β4 integrin signalling and are involved in promoting carcinoma invasion, highlighting a novel function for this family of transcription factors in human cancer. Expand
Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities
TLDR
Deregulating the expression of the mouse Pax-2 gene results in histologically abnormal and dysfunctional renal epithelium with properties similar to congenital nephrotic syndrome and repression of Pax-1 is required for normal kidney development and persistent expression of Pax1 may restrict the differentiation potential of renal epithelial cells. Expand
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