Loss of NF1 allele in Schwann cells but not in fibroblasts derived from an NF1-associated neurofibroma.

@article{Kluwe1999LossON,
  title={Loss of NF1 allele in Schwann cells but not in fibroblasts derived from an NF1-associated neurofibroma.},
  author={Lan Kluwe and Reinhard Edgar Friedrich and Victor Felix Mautner},
  journal={Genes, chromosomes & cancer},
  year={1999},
  volume={24 3},
  pages={283-5}
}
Neurofibromas, the hallmark of neurofibromatosis 1, are composed mainly of Schwann cells and fibroblasts. Inactivation of both NF1 alleles is the cause of these benign tumors, but it is unknown which cell type is the progenitor. In this study, we selectively cultured Schwann cells from an NF1-associated neurofibroma. Fibroblasts were also obtained by culturing the tumor cells under standard conditions. Using four intragenic markers, we genotyped the NF1 locus in the original tumor and in the… CONTINUE READING