Loss of Membranous Expression of β-Catenin Is Associated with Tumor Progression in Cutaneous Melanoma and Rarely Caused by Exon 3 Mutations

Abstract

β-Catenin plays a fundamental role in the regulation of the E-cadherin–catenin cell adhesion complex. It also plays a role in the Wnt signaling pathway by activating T-cell factor– and lymphoid enhancer factor–regulated gene transcription. The level of β-catenin in cells is tightly controlled in a multiprotein complex, and mutations in the glycogen synthase… (More)
DOI: 10.1038/modpathol.3880546

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