Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation.

@article{Heuser2009LossOM,
  title={Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation.},
  author={Michael Heuser and Damian Yap and Malina Leung and Teresa Ruiz de Algara and Alaeddin Tafech and Steven McKinney and John B. Dixon and Rosemary R Thresher and Bill Colledge and Mark B. L. Carlton and Richard Keith Humphries and Samuel Aparicio},
  journal={Blood},
  year={2009},
  volume={113 7},
  pages={1432-43}
}
MLL5 is a divergent member of the Drosophila Trithorax-related (SET) domain and plant homeodomain (PHD) domain-containing chromatin regulators that are involved in the regulation of transcriptional "memory" during differentiation. Human MLL5 is located on chromosome 7q22, which frequently is deleted in myeloid leukemias, suggesting a possible role in hemopoiesis. To address this question, we generated a loss-of-function allele (Mll5(tm1Apa)) in the murine Mll5 locus. Unlike other Mll genes… CONTINUE READING