Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure.

  title={Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure.},
  author={Robert L Thomas and David H Roberts and Dieter A. Kubli and Youngil Lee and Melissa N. Quinsay and Jarvis B Owens and Kimberlee M Fischer and Mark A Sussman and Shigeki Miyamoto and {\AA} B Gustafsson},
  journal={Genes & development},
  volume={27 12},
Myeloid cell leukemia-1 (MCL-1) is an anti-apoptotic BCL-2 protein that is up-regulated in several human cancers. MCL-1 is also highly expressed in myocardium, but its function in myocytes has not been investigated. We generated inducible, cardiomyocyte-specific Mcl-1 knockout mice and found that ablation of Mcl-1 in the adult heart led to rapid cardiomyopathy and death. Although MCL-1 is known to inhibit apoptosis, this process was not activated in MCL-1-deficient hearts. Ultrastructural… CONTINUE READING
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