Loss of Lypd6 leads to reduced anxiety-like behaviour and enhanced responses to nicotine

@article{Arvaniti2017LossOL,
  title={Loss of Lypd6 leads to reduced anxiety-like behaviour and enhanced responses to nicotine},
  author={Maria Jensen Arvaniti and Filip S. Polli and Kristi A Kohlmeier and Morten Sk{\o}tt Thomsen and Jesper Tobias Andreasen},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2017},
  volume={82},
  pages={86-94}
}
Nicotine consumption through smoking affects anxious states in humans. However, the precise role of nicotinic acetylcholine receptor (nAChR) circuitry in the regulation of anxiety remains elusive. The Lynx protein Lypd6 is highly enriched in synaptic loci and has been previously identified as an endogenous inhibitor of neuronal nAChR function in vitro. Here, we investigate the effect of Lypd6 in anxiety-related behaviour and examine the molecular underpinnings of its function in the brain. We… CONTINUE READING

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