Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas.

  title={Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas.},
  author={Cristina M. Contreras and Sushma Gurumurthy and J. Marshall Haynie and Lane J Shirley and Esra A. Akbay and Shana N. Wingo and John Schorge and Russell R. Broaddus and Kwok-kin Wong and Nabeel Bardeesy and Diego H. Castrillon},
  journal={Cancer research},
  volume={68 3},
Mutations in the LKB1 tumor suppressor gene result in the Peutz-Jeghers syndrome, an autosomal dominant condition characterized by hamartomatous polyps of the gastrointestinal tract and a dramatically increased risk of epithelial malignancies at other sites, including the female reproductive tract. Here we show that female mice heterozygous for a null Lkb1 allele spontaneously develop highly invasive endometrial adenocarcinomas. To prove that these lesions were indeed due to Lkb1 inactivation… CONTINUE READING
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