Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila.

@article{Lee2007LossOL,
  title={Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila.},
  author={Sung Bae Lee and Wonho Kim and Sungkyu Lee and Jongkyeong Chung},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={358 2},
  pages={534-9}
}
Mutations in LRRK2/PARK8 are linked to autosomal dominant forms of Parkinson's disease, but the pathogenic mechanism of LRRK2-associated Parkinson's disease is not fully understood. Moreover, in vivo functions of LRRK2 have not been addressed so far. Thus, we generated and characterized transgenic animals and loss-of-function mutants for LRRK, a sole Drosophila orthologue of human LRRK2. While transgenic expression of pathogenic mutant and wild type LRRK did not show any significant defects… CONTINUE READING

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