Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference

@article{Lehner2005LossOL,
  title={Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference},
  author={Ben Lehner and Andrea Calixto and Catriona Crombie and Julia Tischler and Angelo Fortunato and Martin Chalfie and Andrew G. Fraser},
  journal={Genome Biology},
  year={2005},
  volume={7},
  pages={R4 - R4}
}
Genome-wide RNA interference (RNAi) screening is a very powerful tool for analyzing gene function in vivo in Caenorhabditis elegans. The effectiveness of RNAi varies from gene to gene, however, and neuronally expressed genes are largely refractive to RNAi in wild-type worms. We found that C. elegans strains carrying mutations in lin-35, the worm ortholog of the tumor suppressor gene p105Rb, or a subset of the genetically related synMuv B family of chromatin-modifying genes, show increased… CONTINUE READING

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