Loss of Imprinting of the Insulin-like Growth Factor 2 Gene and Risk of Colorectal Cancer

@inproceedings{ZhaoLossOI,
  title={Loss of Imprinting of the Insulin-like Growth Factor 2 Gene and Risk of Colorectal Cancer},
  author={Ronghua Zhao and Marcia Cruz-Correa}
}
The insulin-like growth factor 2 (IGF2) gene is the first gene discovered to be imprinted and expressed exclusively from the paternal allele in both humans and mice. Similarly, IGF2 is the first imprinted gene displaying loss of imprinting (LOI) in human cancers. LOI of IGF2 results in activation of the normally silent maternal allele, with increased IGF2… CONTINUE READING