Loss of Imprinting of IGF2 as an Epigenetic Marker for the Risk of Human Cancer

Abstract

IGF2 is the first gene discovered to be imprinted and expressed exclusively from the paternal allele in both human and mouse. IGF2 is also the first imprinted gene displaying loss of imprinting (LOI) or aberrant imprinting in human cancers. Evidently, LOI or reactivation of the maternal allele of IGF2 is associated with an increase of IGF2 expression that… (More)

Topics

1 Figure or Table

Cite this paper

@inproceedings{Cui2007LossOI, title={Loss of Imprinting of IGF2 as an Epigenetic Marker for the Risk of Human Cancer}, author={Hengmi Cui}, booktitle={Disease markers}, year={2007} }