Loss of IGF-II imprinting in endometrial tumors: overexpression in carcinosarcoma.

@article{Roy2000LossOI,
  title={Loss of IGF-II imprinting in endometrial tumors: overexpression in carcinosarcoma.},
  author={R Neil Roy and Alan Gerulath and Anthony Cecutti and Bhagu R Bhavnani},
  journal={Cancer letters},
  year={2000},
  volume={153 1-2},
  pages={67-73}
}
The genomic imprinting of the maternal allele defines the monoallelic expression of the IGF-II gene in most human tissues. The loss of imprinting (LOI) leading to biallelic overexpression of IGF-II has been reported in several human malignancies, including uterine leiomyosarcoma. To ascertain if LOI occurs in endometrial malignancies, the allelic expression… CONTINUE READING